منابع مشابه
Going their own way in the NPC
Going their own way in the NPC T here’s more than one way to pass through a nuclear pore, as Terry and Wente show. Different cargos follow different routes through the channels, suggesting a new mechanism for regulating import and export. A nuclear pore is a bit like a high school hallway, with molecules and their carriers crowding through in both directions. As they make the crossing, carriers...
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Compelling functional studies link nucleolar and spindle associated protein 1 (NUSAP1) with prostate cancer progression to metastasis; the findings highlight a new value of NUSAP1 as a biomarker of tumor recurrence and therapeutic targeting in pre-clinical models of advanced prostate cancer. Prostate cancer accounted for an estimated 26,120 deaths in the United States in 2016. The majority of t...
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As CGAP carves out the foundation for a new era of molecular diagnostics in cancer, many already have begun thinking about the next steps. Klausner said recently, "You have to have the white pages [a complete index of expressed cancer genes]. But you also need the yellow pages to access, read, and coordinate what's in the white pages." Until then, cancer researchers should expect over the next ...
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The synthesis of cytoplasmic eukaryotic ribosomes is an extraordinarily energy-demanding cellular activity that occurs progressively from the nucleolus to the cytoplasm. In the nucleolus, precursor rRNAs associate with a myriad of trans-acting factors and some ribosomal proteins to form pre-ribosomal particles. These factors include snoRNPs, nucleases, ATPases, GTPases, RNA helicases, and a vas...
متن کاملDo iconic gestures pave the way for children's early verbs?
Children produce a deictic gesture for a particular object (point at dog) approximately three months before they produce the verbal label for that object ("dog") (Iverson & Goldin-Meadow, 2005). Gesture thus paves the way for children's early nouns. We ask here whether the same pattern-gesture preceding and predicting speech-holds for iconic gestures-that is, do gestures that depict actions pre...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2011
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.2038611